Losartan treatment was also generally well tolerated. Losartan which contains potassium can help kidney disease patients lower their high blood pressure effectively, which will be good for kidney disease patients. Dose Hypertension . Losartan helps the kidneys in certain conditions like diabetes. Renal Protection in Type 2 Diabetic Patients with Proteinuria . Background . Shen PC 1, He LQ ... Nondiabetic chronic kidney disease (CKD) is the leading major cause of end-stage renal disease in developing countries including China. 6. 4.2 Dose and method of administration . Y. Iino, M. Hayashi, T. Kawamura et al., “Renoprotective effect of losartan in comparison to amlodipine in patients with chronic kidney disease and hypertension—a report of the Japanese Losartan Therapy Intended for the Global Renal Protection in Hypertensive Patients (JLIGHT) study,” Hypertension Research, vol. 328-335. The losartan renal protection study–rationale, study design and baseline characteristics of RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) J Renin Angiotensin Aldosterone Syst, 1 (2000), pp. Renal Division, Brigham and Women's Hospital, Boston, MA, USA, [email protected] bics.bwh.harvard.edu See all articles by this author. Losartan is used alone or together with other medicines to treat high blood pressure (hypertension). A.S. Levey, J.P. Bosch, J.B. Lewis, et al.A more accurate method to estimate glomerular filtration … I hope this helps. The drugs featured an expiration date of June, 2020, which may be printed on the label as 06/2020. Our study establishes that losartan, along with conventional antihypertensive treatment as needed, confers strong renal protection in patients with type 2 diabetes and nephropathy. My body was intolerant of the latter owing to such swelling and inflammation in my lower legs, the discolouration unfortunately becoming a permanent fixture after discontuing the drug. With losartan, proteinuria was reduced by 35% compared with placebo (p<0.001). With CKD 3b and a sole kidney, I have experience of both Losartan and Amlodipine. Healthy kidneys excrete creatinine in the urine, so a buildup of creatinine in the blood shows that the kidneys aren’t working well. N Engl J Med. We compared the effects of losartan (L) and chlorthalidone (C) on renal vascular resistance index (RVRI) in 194 grade I to II, non-diabetic hypertensive patients with increased RVRI (>0.68 m/s by echo-Doppler) but normal renal function. The common side effects include dizziness, low blood pressure, skin rashes, diarrhea and migraine. It also improves your survival if you're taking it for heart failure or after a heart attack. 22. This medicine is only available on prescription. Losartan is an orally active, selective, nonpeptide, angiotensin II AT 1 receptor antagonist. Lewis EJ, Hunsicker LG, Clarke WR et al. If you have more questions, just reply. Category: Medical. The renal uric acid transporter (URAT1) was shown to be involved in the effect of ARBs on SUA level. Losartan and pratosartan have been found to be potent inhibitors of URAT1. The RENAAL study was a double-blind, randomized, placebo-controlled trial comparing the renal protective effects of losartan on a background of conventional antihypertensive therapies in more than 1,500 patients with type 2 diabetes and nephropathy. By measuring the concentration of creatinine in the bloodstream and using it in an equation that takes into account the person’s weight, age, sex, and race, doctors can estimate the GFR and get a sense of kidney function. Renal protection of losartan 50 mg in normotensive Chinese patients with nondiabetic chronic kidney disease. Listing a study does not mean it has been evaluated by the U.S. Federal Government. A further analysis of 1,428 patients in the RENAAL study showed that albuminuria reduction was associated with a lower risk of ESRD. Barry M Brenner. Read our disclaimer for details. Doctors prescribe it to treat hypertension and nephropathy, which is damage to the kidneys… If it continues for a long time, the heart and arteries may not function properly. Renal allograft protection with losartan in Fisher→Lewis rats: Hemodynamics, macrophages and cytokines. However, as all the western medicines can cause side effects to people and losartan can also cause side effects to people. Barry M Brenner. RESEARCH DESIGN AND METHODS We conducted a 6-year clinical trial in 169 American Indians with type 2 diabetes and urine albumin/creatinine ratio <300 mg/g; 84 participants were randomly assigned to receive losartan and 85 to placebo. Renoprotective effect of the angiotensin‐receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. Adherence by treatment with losartan or placebo was similar in both the normoalbuminuria (32 of 45 in the losartan group, 29 of 46 in the placebo group; P = 0.51) and microalbuminuria (29 of 39 in the losartan group, 29 of 39 in the placebo group; P = 1.00) groups. From the WebMD Archives. 2001 ; 345: 851 –860. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. Losartan is a medicine widely used to treat high blood pressure and heart failure, and to protect your kidneys if you have both kidney disease and diabetes. Satisfied Customers: 74,117. 2001; 345: 861 –869. However, because of the short study duration, the long-term efficacy of losartan in renal protection should be further evaluated.36. N Engl J Med. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. A Study to Evaluate Whether Losartan Protects the Kidney in Hypertensive Diabetic Participants With Microalbuminuria (MK0954-365 AM1) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. By Peggy Peck. LOSARTAN ACTAVIS is indicated to delay the progression of renal disease as measured by a reduction in the combined incidence of doubling of serum creatinine, end stage renal disease (need for dialysis or renal transplantation) or death; and to reduce proteinuria. 2001;345(12):861-9. Long-term comparison of losartan and enalapril on kidney function in hypertensive type 2 diabetics with early nephropathy. Treatment with losartan attenuated CIH-induced renal tissue damage, suggesting that activation of RAS is the primary cascade involved in CIH-induced kidney injury. 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